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Journal of Bacteriology, July 2009, p. 4465-4472, Vol. 191, No. 13
0021-9193/09/$08.00+0     doi:10.1128/JB.01729-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Characterization of the Corynebacterium glutamicum {Delta}pimB' {Delta}mgtA Double Deletion Mutant and the Role of Mycobacterium tuberculosis Orthologues Rv2188c and Rv0557 in Glycolipid Biosynthesis{triangledown}

Arun K. Mishra,1 Sarah Batt,1 Karin Krumbach,2 Lothar Eggeling,2 and Gurdyal S. Besra1*

School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom,1 Institute for Biotechnology 1, Research Centre Juelich, D-52425 Juelich, Germany2

Received 10 December 2008/ Accepted 10 April 2009

In this study, utilizing a Corynebacterium glutamicum {Delta}pimB' {Delta}mgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac1PIM1:mannosyltransferase (originally termed PimB'Mt [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc2:mannosyltransferase (originally termed PimBMt), which we have reassigned as PimBMt and MgtAMt, respectively, in Mycobacterium tuberculosis.

* Corresponding author. Mailing address: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Phone: 44 121 415 8125. Fax: 44 121 414 5925. E-mail: g.besra{at}bham.ac.uk

{triangledown} Published ahead of print on 24 April 2009.

Journal of Bacteriology, July 2009, p. 4465-4472, Vol. 191, No. 13
0021-9193/09/$08.00+0     doi:10.1128/JB.01729-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Guerin, M. E., Kaur, D., Somashekar, B. S., Gibbs, S., Gest, P., Chatterjee, D., Brennan, P. J., Jackson, M. (2009). New Insights into the Early Steps of Phosphatidylinositol Mannoside Biosynthesis in Mycobacteria: PimB' IS AN ESSENTIAL ENZYME OF MYCOBACTERIUM SMEGMATIS. J. Biol. Chem. 284: 25687-25696 [Abstract] [Full Text]  


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