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Journal of Bacteriology, July 2009, p. 4482-4484, Vol. 191, No. 13
0021-9193/09/$08.00+0     doi:10.1128/JB.00221-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Wall Teichoic Acid Protects Staphylococcus aureus against Antimicrobial Fatty Acids from Human Skin{triangledown}

Thomas Kohler,1 Christopher Weidenmaier,2 and Andreas Peschel1*

Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tübingen, Tübingen, Germany,1 Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts2

Received 19 February 2009/ Accepted 29 April 2009

Skin-colonizing gram-positive bacteria produce wall teichoic acids (WTAs) or related glycopolymers for unclear reasons. Using a WTA-deficient Staphylococcus aureus mutant, we demonstrated that WTA confers resistance to antimicrobial fatty acids from human sebaceous glands by preventing fatty acid binding. Thus, WTA is probably important for bacterial skin colonization.

* Corresponding author. Mailing address: Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tübingen, Tübingen, Germany. Phone: (49)-7071-2981515. Fax: (49)-7071-293435. E-mail: andreas.peschel{at}uni-tuebingen.de

{triangledown} Published ahead of print on 8 May 2009.

Journal of Bacteriology, July 2009, p. 4482-4484, Vol. 191, No. 13
0021-9193/09/$08.00+0     doi:10.1128/JB.00221-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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