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Journal of Bacteriology, January 2009, p. 665-672, Vol. 191, No. 2
0021-9193/09/$08.00+0     doi:10.1128/JB.00941-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Transcriptional Modulator NusA Interacts with Translesion DNA Polymerases in Escherichia coli{triangledown}

Susan E. Cohen,1,{dagger} Veronica G. Godoy,2,{dagger} and Graham C. Walker1*

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139,1 Department of Biology, Northeastern University, Boston, Massachusetts 021152

Received 9 July 2008/ Accepted 28 October 2008

NusA, a modulator of RNA polymerase, interacts with the DNA polymerase DinB. An increased level of expression of dinB or umuDC suppresses the temperature sensitivity of the nusA11 strain, requiring the catalytic activities of these proteins. We propose that NusA recruits translesion DNA synthesis (TLS) polymerases to RNA polymerases stalled at gaps, coupling TLS to transcription.

* Corresponding author. Mailing address: Department of Biology, 68-633, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139. Phone: (617) 253-6716. Fax: (617) 253-2643. E-mail: gwalker{at}mit.edu

{triangledown} Published ahead of print on 7 November 2008.

{dagger} S.E.C. and V.G.G. contributed equally to this work.

Journal of Bacteriology, January 2009, p. 665-672, Vol. 191, No. 2
0021-9193/09/$08.00+0     doi:10.1128/JB.00941-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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