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Journal of Bacteriology, February 2009, p. 1092-1096, Vol. 191, No. 3
0021-9193/09/$08.00+0     doi:10.1128/JB.01431-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Nanoarchaeal Origin of Histone H3? {triangledown}

Ulrike Friedrich-Jahn,1,{dagger} Johanna Aigner,1 Gernot Längst,2 John N. Reeve,3 and Harald Huber1*

Institute for Microbiology and Archaeal Center, University of Regensburg, D-93053 Regensburg, Germany,1 Department of Biochemistry III, University of Regensburg, D-93053 Regensburg, Germany,2 Department of Microbiology, Ohio State University, Columbus, Ohio 432103

Received 13 October 2008/ Accepted 20 November 2008

NEQ288, one of two archaeal histones in Nanoarchaeum equitans, has a unique four-residue insertion that closely resembles an insertion in the eukaryotic histone H3 lineage. NEQ288 bound DNA but did not compact DNA in vitro in the absence of NEQ348, the second N. equitans archaeal histone. The properties of NEQ288 suggest an intermediate between the archaeal and H3 histone lineages and an evolutionary step toward the now-mandatory assembly of eukaryotic histones into heterodimers.

* Corresponding author. Mailing address: Lehrstuhl für Mikrobiologie und Archaeenzentrum, Universität Regensburg, Universitätsstrasse 31, D-93053 Regensburg, Germany. Phone: 49-941-9433185. Fax: 49-941-9432403. E-mail: Harald.huber{at}biologie.uni-regensburg.de

{triangledown} Published ahead of print on 1 December 2008.

{dagger} Present address: Institut für Humangenetik, Universitätsklinikum Bauteil D3, Franz-Josef-Strauss-Allee 11, D-93053, Regensburg, Germany.

Journal of Bacteriology, February 2009, p. 1092-1096, Vol. 191, No. 3
0021-9193/09/$08.00+0     doi:10.1128/JB.01431-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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