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Journal of Bacteriology, February 2009, p. 1097-1100, Vol. 191, No. 3
0021-9193/09/$08.00+0     doi:10.1128/JB.00862-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Growth Conditions Regulate the Requirements for Caulobacter Chromosome Segregation{triangledown} ,{dagger}

Conrad W. Shebelut,1 Rasmus B. Jensen,2,{ddagger} and Zemer Gitai1*

Department of Molecular Biology, Princeton University, Washington Rd., Princeton, New Jersey 08544,1 Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK-4000 Roskilde, Denmark2

Received 24 June 2008/ Accepted 14 November 2008

Growth environments are important metabolic and developmental regulators. Here we demonstrate a growth environment-dependent effect on Caulobacter chromosome segregation of a small-molecule inhibitor of the MreB bacterial actin cytoskeleton. Our results also implicate ParAB as important segregation determinants, suggesting that multiple distinct mechanisms can mediate Caulobacter chromosome segregation and that their relative contributions can be environmentally regulated.

* Corresponding author. Mailing address: Department of Molecular Biology, Princeton University, Washington Rd., Princeton, NJ 08544. Phone: (609) 258-2877. Fax: (609) 258-3980. E-mail: zgitai{at}princeton.edu

{triangledown} Published ahead of print on 21 November 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

{ddagger} Present address: LEO Pharma, Industriparken 55, DK-2750 Ballerup, Denmark.

Journal of Bacteriology, February 2009, p. 1097-1100, Vol. 191, No. 3
0021-9193/09/$08.00+0     doi:10.1128/JB.00862-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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