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Journal of Bacteriology, February 2009, p. 1115-1117, Vol. 191, No. 3
0021-9193/09/$08.00+0     doi:10.1128/JB.01260-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Chenodeoxycholate Is an Inhibitor of Clostridium difficile Spore Germination{triangledown}

Joseph A. Sorg and Abraham L. Sonenshein*

Department of Molecular Biology and Microbiology, Tufts University, School of Medicine, Boston, Massachusetts

Received 8 September 2008/ Accepted 26 November 2008

Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111. Phone: (617) 636-6761. Fax: (617) 636-0337. E-mail: linc.sonenshein{at}tufts.edu

{triangledown} Published ahead of print on 5 December 2008.

Journal of Bacteriology, February 2009, p. 1115-1117, Vol. 191, No. 3
0021-9193/09/$08.00+0     doi:10.1128/JB.01260-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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