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Journal of Bacteriology, April 2009, p. 2414-2418, Vol. 191, No. 7
0021-9193/09/$08.00+0     doi:10.1128/JB.01258-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Functional Analysis of Insertion Sequence ISAba1, Responsible for Genomic Plasticity of Acinetobacter baumannii{triangledown}

Pauline D. Mugnier, Laurent Poirel, and Patrice Nordmann*

Service de Bactériologie-Virologie, INSERM U914: "Emerging Resistance to Antibiotics," Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Sud, 94275 Le Kremlin-Bicêtre, France

Received 8 September 2008/ Accepted 2 January 2009

ISAba1 is an insertion sequence that is widely distributed in Acinetobacter baumannii. We demonstrated here that ISAba1 and the composite transposon Tn2006 are capable of transposition, generating 9-bp target site duplications. The expression of the ISAba1 transposase-encoding gene was downregulated by translational frameshifting.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.aphp.fr

{triangledown} Published ahead of print on 9 January 2009.

Journal of Bacteriology, April 2009, p. 2414-2418, Vol. 191, No. 7
0021-9193/09/$08.00+0     doi:10.1128/JB.01258-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Figueiredo, S., Poirel, L., Croize, J., Recule, C., Nordmann, P. (2009). In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 Oxacillinase Gene. Antimicrob. Agents Chemother. 53: 2657-2659 [Abstract] [Full Text]  


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