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Journal of Bacteriology, April 2009, p. 2743-2752, Vol. 191, No. 8
0021-9193/09/$08.00+0     doi:10.1128/JB.01519-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Regulation of igaA and the Rcs System by the MviA Response Regulator in Salmonella enterica{triangledown}

Clara B. García-Calderón, Josep Casadesús, and Francisco Ramos-Morales*

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, 41080 Seville, Spain

Received 27 October 2008/ Accepted 8 February 2009

IgaA is a membrane protein that prevents overactivation of the Rcs regulatory system in enteric bacteria. Here we provide evidence that igaA is the first gene in a {sigma}70-dependent operon of Salmonella enterica serovar Typhimurium that also includes yrfG, yrfH, and yrfI. We also show that the Lon protease and the MviA response regulator participate in regulation of the igaA operon. Our results indicate that MviA regulates igaA transcription in an RpoS-dependent manner, but the results also suggest that MviA may regulate RcsB activation in an RpoS- and IgaA-independent manner.

* Corresponding author. Mailing address: Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avda Reina Mercedes, 6, 41012 Seville, Spain. Phone: 34 95 455 7107. Fax: 34 95 455 7104. E-mail: framos{at}us.es

{triangledown} Published ahead of print on 13 February 2009.

Journal of Bacteriology, April 2009, p. 2743-2752, Vol. 191, No. 8
0021-9193/09/$08.00+0     doi:10.1128/JB.01519-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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