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Journal of Bacteriology, April 2009, p. 2902-2905, Vol. 191, No. 8
0021-9193/09/$08.00+0     doi:10.1128/JB.01721-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Rrp2, a {sigma}54-Dependent Transcriptional Activator of Borrelia burgdorferi, Activates rpoS in an Enhancer-Independent Manner{triangledown} ,{dagger}

Jon S. Blevins,1,2 Haijun Xu,3 Ming He,3 Michael V. Norgard,2 Larry Reitzer,4 and X. Frank Yang3*

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205,1 Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,2 Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202,3 Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 750834

Received 9 December 2008/ Accepted 27 January 2009

Rrp2 is the sole {sigma}54-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates {sigma}54-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other {sigma}54-dependent transcriptional activators.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202. Phone: (317) 274-7671. Fax: (317) 274-4090. E-mail: xfyang{at}iupui.edu

{triangledown} Published ahead of print on 6 February 2009.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, April 2009, p. 2902-2905, Vol. 191, No. 8
0021-9193/09/$08.00+0     doi:10.1128/JB.01721-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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  • Sanjuan, E., Esteve-Gassent, M. D., Maruskova, M., Seshu, J. (2009). Overexpression of CsrA (BB0184) Alters the Morphology and Antigen Profiles of Borrelia burgdorferi. Infect. Immun. 77: 5149-5162 [Abstract] [Full Text]  


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