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Journal of Bacteriology, May 2009, p. 3162-3167, Vol. 191, No. 9
0021-9193/09/$08.00+0     doi:10.1128/JB.01777-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

A Conserved Gene Cluster Rules Anaerobic Oxidative Degradation of L-Ornithine{triangledown}

Nuria Fonknechten,1,2,3*,{dagger} Alain Perret,1,2,3*,{dagger} Nadia Perchat,1,2,3 Sabine Tricot,1,2,3 Christophe Lechaplais,1,2,3 David Vallenet,1,2,3 Carine Vergne,1,2,3 Anne Zaparucha,1,2,3 Denis Le Paslier,1,2,3 Jean Weissenbach,1,2,3 and Marcel Salanoubat1,2,3

CEA, DSV, IG, Genoscope, 2 rue Gaston Crémieux, Evry F-91057, France,1 CNRS-UMR 8030, Evry F-91057, France,2 UEVE, Université d'Evry, Evry F-91057, France3

Received 18 December 2008/ Accepted 14 February 2009

For the ornithine fermentation pathway, described more than 70 years ago, genetic and biochemical information are still incomplete. We present here the experimental identification of the last four missing genes of this metabolic pathway. They encode L-ornithine racemase, (2R,4S)-2,4-diaminopentanoate dehydrogenase, and the two subunits of 2-amino-4-ketopentanoate thiolase. While described only for the Clostridiaceae to date, this pathway is shown to be more widespread.

* Corresponding author. Mailing address: CEA, DSV, IG, Genoscope, 2 rue Gaston Crémieux, Evry F-91057, France. Phone: (33) 1 60 87 45 90. Fax: (33) 1 60 87 25 14. E-mail for Nuria Fonknechten: fonk{at}genoscope.cns.fr. E-mail for Alain Perret: aperret{at}genoscope.cns.fr

{triangledown} Published ahead of print on 27 February 2009.

{dagger} These authors contributed equally to this work.

Journal of Bacteriology, May 2009, p. 3162-3167, Vol. 191, No. 9
0021-9193/09/$08.00+0     doi:10.1128/JB.01777-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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