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Journal of Bacteriology, May 2009, p. 3177-3182, Vol. 191, No. 9
0021-9193/09/$08.00+0     doi:10.1128/JB.00011-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Stationary-Phase Sigma Factor {sigma}S Is Responsible for the Resistance of Escherichia coli Stationary-Phase Cells to mazEF-Mediated Cell Death{triangledown}

Ilana Kolodkin-Gal and Hanna Engelberg-Kulka*

Department of Molecular Biology, the Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

Received 5 January 2009/ Accepted 11 February 2009

Escherichia coli mazEF is a toxin-antitoxin gene module that mediates cell death during exponential-phase cellular growth through either reactive oxygen species (ROS)-dependent or ROS-independent pathways. Here, we found that the stationary-phase sigma factor {sigma}S was responsible for the resistance to mazEF-mediated cell death during stationary growth phase. Deletion of rpoS, the gene encoding {sigma}S from the bacterial chromosome, permitted mazEF-mediated cell death during stationary growth phase.

* Corresponding author. Mailing address: Department of Molecular Biology, the Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel. Phone: 972-2-6758250. Fax: 972-2-678-4010. E-mail: hanita{at}cc.huji.ac.il

{triangledown} Published ahead of print on 27 February 2009.

Journal of Bacteriology, May 2009, p. 3177-3182, Vol. 191, No. 9
0021-9193/09/$08.00+0     doi:10.1128/JB.00011-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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