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 Previous Article

Journal of Bacteriology, May 2009, p. 3189-3194, Vol. 191, No. 9
0021-9193/09/$08.00+0     doi:10.1128/JB.01771-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

vfr, a Novel Locus Affecting Cysteine Protease Production in Streptococcus pyogenes{triangledown}

Yongsheng Ma,1,2* Amy E. Bryant,1,3 Dan B. Salmi,1 Eric McIndoo,1 and Dennis L. Stevens1,3

Veterans Affairs Medical Center, Infectious Diseases Section, Boise, Idaho,1 Idaho State University, Pocatello, Idaho,2 University of Washington School of Medicine, Seattle, Washington3

Received 17 December 2008/ Accepted 23 February 2009

A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.

* Corresponding author. Mailing address: Research Scientist, Research & Development Service, Veterans Affairs Medical Center, 500 West Fort St. (Bldg. 45), Boise, ID 83702. Phone: (208) 422-1599. Fax: (208) 422-1365. E-mail: yongsheng.ma{at}va.gov

{triangledown} Published ahead of print on 6 March 2009.

Journal of Bacteriology, May 2009, p. 3189-3194, Vol. 191, No. 9
0021-9193/09/$08.00+0     doi:10.1128/JB.01771-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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