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J Bacteriol. 1966 November; 92(5): 1290-1297
Copyright © 1966 American Society for Microbiology. All Rights Reserved.

Autochthonous Intestinal Bacterial Flora and Cholesterol Levels in Specific Pathogen-free Swine Fed High-Lipid and High-Sucrose Diets

C. D. Graber1, R. W. Moore, M. Suzuki, W. E. Redmond, R. M. O'Neal and B. M. Lockhart

Departments of Microbiology and Pathology, Baylor University College of Medicine, Houston, Texas
College of Veterinary Medicine, Texas A & M, College Station, Texas

ABSTRACT

GRABER, C. D. (Baylor University College of Medicine, Houston, Tex.). R. W. MOORE, M. SUZUKI, W. E. REDMOND, R. M. O'NEAL, AND B. M. LOCKHART. Autochthonous intestinal bacterial flora and cholesterol levels in specific pathogen-free swine fed high-lipid and high-sucrose diets. J. Bacteriol. 92:1290–1297. 1966.—Thirty-two specific pathogen-free (SPF) and conventional swine fed high fat, high sugar, and a standard ration were cultured for intestinal flora, and their blood cholesterol levels were measured. The diets, whether sterilized or not sterilized, fed ad libitum or restricted, did not alter bacterial flora greatly or influence blood cholesterol levels. Anaerobes outnumbered aerobes by several logs. Four autochthonous bacteria, lactobacilli, Escherichia coli, enterococci, and gram-variable, nonspore-forming anaerobes (GVNSA; a type of bacteroides), were shown to be constantly present in all animals regardless of dietary conditions. From the duodenum and jejunum of 14 pigs, GVNSA and Bacteroides nigrescens were cultured in rather large numbers, a finding not previously reported in swine or in most other mammals. This finding may have special significance in reference to bile acid and cholesterol metabolism.

FOOTNOTES

1 Present address: Department of Microbiology, Medical College of South Carolina, Charleston.

J Bacteriol. 1966 November; 92(5): 1290-1297
Copyright © 1966 American Society for Microbiology. All Rights Reserved.





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