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J Bacteriol. 1967 February; 93(2): 716-721
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Platinum-Induced Filamentous Growth in Escherichia coli1

Barnett Rosenberg, Earl Renshaw2, Loretta Vancamp, John Hartwick and Jaroslav Drobnik3

a Biophysics Department, Michigan State University, East Lansing, Michigan

ABSTRACT

Certain group VIIIB transition metal compounds were found to inhibit cell division in Escherichia coli, causing marked filamentous growth. Gram-negative bacilli were the most sensitive to this effect, whereas gram-positive bacilli responded only at near-toxic levels of the metal. None of the cocci tested showed any apparent effect. Cytokinesis (cross-septation) can be initiated by removal or decrease of platinum, but not by treatment with pantoyl lactone, divalent cations, or a temperature of 42 C.

FOOTNOTES

2 Present address: Michigan Department of Public Health Laboratories, Lansing, Mich.

3 Present address: Faculty of Science, Division of Biophysics, Charles University, Prague, Czechoslovakia.

1 Presented in part at the 66th Annual Meeting of the American Society for Microbiology, Los Angeles, Calif., May 1966.

J Bacteriol. 1967 February; 93(2): 716-721
Copyright © 1967 American Society for Microbiology. All Rights Reserved.



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  • ROZENCWEIG, M., VON HOFF, D. D., SLAVIK, M., MUGGIA, F. M. (1977). Cis-diamminedichloroplatinum (II) A New Anticancer Drug. ANN INTERN MED 86: 803-812 [Abstract]  


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