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J. Bacteriol. doi:10.1128/JB.00003-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Control of Quorum Sensing by a Burkholderia pseudomallei Multidrug Efflux Pump

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597; Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave., Madison, WI 53706-1322, USA; Chemical Biology and Biotechnology Lab, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan

^* To whom correspondence should be addressed. Email: bchckl{at}nus.edu.sg.

	Abstract

The Burkholderia pseudomallei KHW quorum sensing systems produced N-octanoyl-homoserine lactone (C8HSL), N-decanoyl-homoserine lactone (C10HSL), N-(3-hydroxy)-octanoyl-homoserine lactone (3-hydroxy-C8HSL), N-(3-hydroxy)-decanoyl-homoserine lactone (3-hydroxy-C10HSL), N-(3-oxo)-decanoyl-homoserine lactone (3-oxo-C10HSL) and N-(3-oxo)-tetradecanoyl-homoserine lactone (3-oxo-C14HSL). The extracellular secretion of these acyl-HSLs is dependent absolutely on the function of its BpeAB-OprB efflux pump.