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J. Bacteriol. doi:10.1128/JB.00008-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Lineage-specific amino acid substitutions in region 2 of the RNA polymerase subunit affect the temperature of promoter opening

Institute of Molecular Genetics, Kurchatov Sq. 2, Moscow 123182, Russia; Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA

^* To whom correspondence should be addressed. Email: akulb{at}img.ras.ru.

	Abstract

Highly conserved amino acid residues from region 2 of the RNA polymerase subunit are known to participate in promoter recognition and opening. We demonstrate that nonconserved residues from this region collectively determine lineage-specific differences in the temperature of promoter opening.