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J. Bacteriol. doi:10.1128/JB.00240-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The anaerobic regulatory network required for Pseudomonas aeruginosa nitrate respiration

Kerstin Schreiber, Robert Krieger, Beatrice Benkert, Martin Eschbach, Hiroyuki Arai, Max Schobert, and Dieter Jahn*

Institute of Microbiology, Technical University of Braunschweig, Spielmannstr. 7, 38106 Braunschweig, Germany; Department of Biotechnology, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan

* To whom correspondence should be addressed. Email: d.jahn{at}tu-bs.de.


  Abstract

In Pseudomonas aeruginosa the narK1K2GHJI operon encodes two nitrate/nitrite transporters and the dissimilatory nitrate reductase. The narK1 promoter is anaerobically induced in the presence of nitrate by the dual activity of the oxygen regulator Anr and the N-oxide regulator Dnr in cooperation with the nitrate responsive two component regulatory system NarXL. The DNA bending protein IHF is essential for this process. Similarly, narXL gene transcription is enhanced under anaerobic conditions by Anr and Dnr. Furthermore, Anr and NarXL induce expression of the N-oxide regulator gene dnr. Finally, NarXL in cooperation with Dnr is required for anaerobic nitrite reductase regulatory gene nirQ transcription. A cascade regulatory model for the fine tuned genetic response of P. aeruginosa to anaerobic growth conditions in the presence of nitrate was deduced.


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