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J. Bacteriol. doi:10.1128/JB.00371-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Deletion of the parA (soj) homologue in Pseudomonas aeruginosa causes ParB instability and affects growth rate, chromosome segregation and motility

Krzysztof Lasocki, Aneta A. Bartosik, Jolanta Mierzejewska, Christopher M. Thomas, and Grazyna Jagura-Burdzy*

The Institute of Biochemistry and Biophysics, PAS, 02-106 Warsaw, Pawinskiego 5A, Poland; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

* To whom correspondence should be addressed. Email: gjburdzy{at}ibbrain.ibb.waw.pl.


  Abstract

The parA and parB genes of Pseudomonas aeruginosa are located approximately 8 kb anticlockwise from oriC. ParA is a cytosolic protein present at around 600 molecules per cell in exponential phase but drops about 5-fold in stationary phase. Over-production of full length ParA or the N-terminal 85 amino acids severely inhibits growth of P. aeruginosa and P. putida. Both inactivation of parA and over-expression of parA in trans in P. aeruginosa also lead to accumulation of anucleate cells and changes in motility. Inactivation of parA also increases the turnover rate (degradation) of ParB. This may provide a mechanism for controlling the level of ParB in response to growth rate and expression of the parAB operon.


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