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J. Bacteriol. doi:10.1128/JB.00411-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Double-strand breaks generation under deoxyribonucleotide starvation in Escherichia coli

Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, 06080-Badajoz, Spain

^* To whom correspondence should be addressed. Email: eguzman{at}unex.es.

	Abstract

Stalled replication forks produced by three different ways of depleting dNTP showed different capacities to undergo "replication fork reversal". This reaction occurred at the stalled forks generated by hydroxyurea treatment, was impaired under thermal inactivation of ribonucleoside reductase, and did not take place under thymine starvation.