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J. Bacteriol. doi:10.1128/JB.00482-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

folA a new member of the TyrR regulon in Escherichia coli K-12

Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia; Department of Frontier Bioscience and Micro-Nano Technology Research Center, Hosei University, Koganei, Tokyo 184-8584, Japan

^* To whom correspondence should be addressed. Email: aj.pittard{at}microbiology.unimelb.edu.au.

	Abstract

The folA gene was identified as a new member of the TyrR regulon by genomic SELEX. Binding of TyrR to two sites in folA activated its transcription. Mutations in the N-terminal or central domains of TyrR, the -subunit of RNA polymerase or IHF all abolished activation of the folA promoter.