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J. Bacteriol. doi:10.1128/JB.00489-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

SbcCD regulation and localization in Escherichia coli

Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, UK

^* To whom correspondence should be addressed. Email: d.leach{at}ed.ac.uk.

	Abstract

The SbcCD complex and its homologues play important roles in DNA repair and in the maintenance of genome stability. In Escherichia coli, the in vitro functions of SbcCD have been well characterized but its exact cellular role remains elusive. This work investigates the regulation of the sbcDC operon and the cellular localization of the SbcC and SbcD proteins. The transcription of the sbcDC operon is shown to be starvation and RpoS-dependent. Over-expressed SbcC protein forms foci that colocalize with the replication factory while over-expressed SbcD protein is distributed through the cytoplasm.