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JB Accepts, published online ahead of print on 22 June 2007
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J. Bacteriol. doi:10.1128/JB.00525-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Genetic Structure of the nadA and nadB Anti-virulence Loci in Shigella spp

Anne-Laure Prunier, Raymond Schuch, Reinaldo E. Fernández, and Anthony T. Maurelli*

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, MD 20814-4799 USA

* To whom correspondence should be addressed. Email: amaurelli{at}usuhs.mil.


  Abstract

Comparison of nadA and nadB in 14 Shigellae and EIEC vs. E. coli showed that at least one locus is altered in all strains. These observations explain the characteristic nicotinic acid auxotrophy of Shigellae and are consistent with the previously identified antivirulence nature of these genes for these pathogens.


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