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JB Accepts, published online ahead of print on 10 August 2007
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J. Bacteriol. doi:10.1128/JB.00547-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

SEQUENCE ANALYSIS OF THE STAPHYLOCOCCUS AUREUS srrAB LOCUS REVEALS THAT TRUNCATION OF srrA AFFECTS GROWTH AND VIRULENCE FACTOR EXPRESSION

Alexa A. Pragman, Lisa Herron-Olson, Laura C. Case, Sara M. Vetter, Evan M. Henke, Vivek Kapur, and Patrick M. Schlievert*

* To whom correspondence should be addressed. Email: schli001{at}umn.edu.


  Abstract

SrrAB regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2, N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression in low oxygen conditions.




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