EbpR is Important for Biofilm Formation by Activating Expression of the Endocarditis and Biofilm-Associated Pilus Operon (ebpABC) of Enterococcus faecalis OG1RF

Division of Infectious Diseases, Department of Medicine, Center for the Study of Emerging and Re-emerging Pathogens, Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 77030, USA

^* To whom correspondence should be addressed. Email: BEM.asst{at}uth.tmc.edu.

	Abstract

Herein we identify ef1090 (renamed ebpR) and show its importance for transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR mutant was found to have reduced ebpABC expression with loss of pilus production, and a defect in primary adherence with, as a consequence, reduced biofilm formation.