J. Bacteriol. doi:10.1128/JB.01040-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.
The Influence of the Hydrodynamic Environment on Quorum Sensing in Pseudomonas aeruginosa Biofilms
Mary Jo Kirisits*,
Jeffrey J. Margolis,
Boloroo L. Purevdorj-Gage,
Benjamin Vaughan,
David L. Chopp,
Paul Stoodley,
and
Matthew R. Parsek*
Department of Civil, Architectural, and Environmental Engineering, The University of Texas at Austin, Austin, Texas 78712; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305; Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717; Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois 60208; Center for Genomic Sciences, Pittsburgh, Pennsylvania 15212; Department of Microbiology, University of Washington, Seattle, Washington 98195
* To whom correspondence should be addressed. Email:
kirisits{at}mail.utexas.edu. parsem{at}u.washington.edu.
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Abstract |
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We provide experimental and modeling evidence that the hydrodynamic environment can impact quorum sensing (QS) in a Pseudomonas aeruginosa biofilm. The amount of biofilm biomass required for full QS induction of the population increased as the flow rate increased.