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J. Bacteriol. doi:10.1128/JB.01084-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Lysine decarboxylase expression of Vibrio vulnificus is induced by SoxR in response to superoxide stress

From the Department of Life Science and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Korea, and School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, Korea

^* To whom correspondence should be addressed. Email: jgklee{at}sogang.ac.kr.

	Abstract

Lysine decarboxylase expression of V. vulnificus, which is up-regulated by CadC in response to acid stress, is also induced by SoxR in response to superoxide stress. SoxR binds to the promoter region of cadBA operon coding for lysine-cadaverine antiporter (CadB) and a lysine decarboxylase (CadA). The induction of cadBA transcription by SoxR is independent of CadC. Cadaverine, which neutralizes the external medium, also appears to scavenge superoxide radicals since the increase of cellular cadaverine by elevating gene dosage of cadBA significantly diminished the induction of Mn-containing superoxide dismutase (MnSOD) under methyl viologen (MV)-induced oxidative stress. Consistently, lack of cadaverine by mutation in cadA resulted in low tolerance to oxidative stress compared with wild type.

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