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J. Bacteriol. doi:10.1128/JB.01124-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Molecular evolution of the H-NS protein: interaction with Hha-like proteins is restricted to Enterobacteriaceae

Cristina Madrid, Jesús García, Miquel Pons, and Antonio Juárez*

Dept. Microbiology, University of Barcelona.Avda. Diagonal 645. 08028 Barcelona, Spain; Laboratory of Biomolecular NMR, Institut de Recerca Biomèdica, Parc Cientific de Barcelona. Josep Samitier 1-5, 08028 Barcelona, Spain

* To whom correspondence should be addressed. Email: ajuarez{at}ub.edu.


   Abstract

We show in this report that chromosomal hha-like genes are restricted to the Enterobacteriaceae. The H-NS N-terminal domain of members of this family includes an unaltered seven-aminoacid sequence, located between helixes 1 and 2, termed Hha signature that contains key residues for H-NS-Hha interaction.




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