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J. Bacteriol. doi:10.1128/JB.01206-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Modulation of horizontally-acquired genes by the Hha-YdgT proteins in Salmonella enterica Serovar Typhimurium

Departament de Microbiologia. Universitat de Barcelona. Avda. Diagonal 645, 08028 Barcelona, Spain, Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain, and BioinfoGP, Centro Nacional de Biotecnología-CSIC, Madrid, Spain

	Abstract

We present a transcriptomic study of the effect of hha and ydgT mutations in S. enterica serovar Typhimurium. A large number of genes showing an altered expression are located in AT-rich horizontally acquired DNA sequences. Many of those genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when silencing these DNA regions.

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