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JB Accepts, published online ahead of print on 3 November 2006
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J. Bacteriol. doi:10.1128/JB.01387-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

A Proteolytic Adaptor for tmRNA-tagged Proteins from {alpha}-proteobacteria

Faith H. Lessner, Bryan J. Venters, and Kenneth C. Keiler*

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802

* To whom correspondence should be addressed. Email: kkeiler{at}psu.edu.


  Abstract

We have identified an analog of SspB, the proteolytic adaptor for tmRNA-tagged proteins, in Caulobacter crescentus. The C. crescentus SspB shares limited sequence similarity with Escherichia coli SspB, but binds the tmRNA tag in vitro and is required for optimal proteolysis of tagged proteins in vivo.


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