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J. Bacteriol. doi:10.1128/JB.01437-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Contribution of invariant residues to function of Rgg family transcription regulators

Departments of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110

^* To whom correspondence should be addressed. Email: Loughman_J{at}kids.wustl.edu.

	Abstract

The Rgg family of transcription regulators is widely distributed among Gram-positive bacteria, yet, how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model we demonstrate that residues invariant among Rgg-like regulators are critical for function, and provide evidence for a mechanism involving protein complex formation.

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