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Institute of Medical Microbiology and Hygiene, Institutes of Infectious Disease Medicine, University of Saarland, Homburg/Saar, Germany; Department of Medicine and Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin, USA; Institute of Medical Microbiology, University Hospital of Münster, Münster, Germany
* To whom correspondence should be addressed. Email: ichatterjee76{at}yahoo.com.
| Abstract |
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The mechanisms of Staphylococcus aureus small colony variant (SCV) persistence are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC and arcA, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.
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