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J. Bacteriol. doi:10.1128/JB.01642-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE vs. SigH

The Genome Research Center for Respiratory Pathogens, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Division of Infectious Diseases, Children's Hospital Boston, Harvard Medical School, Boston, MA

^* To whom correspondence should be addressed. Email: robert.husson{at}childrens.harvard.edu.

	Abstract

Mycobacterial SigE and SigH both initiate transcription from the sigB promoter, suggesting that they recognize similar sequences. Through mutational and primer extension analyses we determined that SigE and SigH recognize nearly identical promoters, with differences at the 3' end of the -35 element distinguishing SigE vs. SigH-dependent promoters.

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