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J. Bacteriol. doi:10.1128/JB.01653-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Evidence that RpoS (^S) in Borrelia burgdorferi is controlled directly by RpoN (⁵⁴/^N)

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202

^* To whom correspondence should be addressed. Email: michael.norgard{at}utsouthwestern.edu.

	Abstract

The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly, or perhaps indirectly via a transactivator, has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.

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