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JB Accepts, published online ahead of print on 6 April 2007
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189/11/4315    most recent
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J. Bacteriol. doi:10.1128/JB.01789-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Interspecies DNA Microarray Analysis Identifies WblA as a Pleiotropic Down-regulator of Antibiotic Biosynthesis in Streptomyces

Seung-Hoon Kang, Jianqiang Huang, Han-Na Lee, Yoon-Ah Hur, Stanley N. Cohen*, and Eung-Soo Kim*

Department of Biological Engineering, Inha University, Incheon 402-751, Korea; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA

* To whom correspondence should be addressed. Email: sncohen{at}stanford.edu. eungsoo{at}inha.ac.kr.


  Abstract

Using Streptomyces coelicolor microarrays to discover regulators of gene expression in other Streptomyces species, we identified wblA, a whiB-like gene encoding a putative transcription factor, as down-regulator of doxorubicin biosynthesis in S. peucetius. Further analysis revealed that wblA functions pleiotropically in streptomycetes. Our results reveal a novel biological role for wblA and show the utility of inter-species microarray analysis for investigation of streptomycete gene expression.




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