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J. Bacteriol. doi:10.1128/JB.01831-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Localization of PcsB of Streptococcus pneumoniae and its differential expression in response to stress

Departments of Microbiology, Surgery, and Medicine, The University of Mississippi Medical Center, Jackson, MS 39216

^* To whom correspondence should be addressed. Email: LMcDaniel{at}microbio.umsmed.edu.

	Abstract

PcsB of Streptococcus pneumoniae is an essential hydrolase involved in the separation of dividing cells. In this study, it was found that PcsB localizes to the plasma membrane and is released into the growth environment; yet it is detectable on the pneumococcal surface by flow cytometry analysis. High temperature and osmolarity led to upregulation of pcsB expression.