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J. Bacteriol. doi:10.1128/JB.01851-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

RecO is essential for DNA damage repair in Deinococcus radiodurans

Key Laboratory of Chinese Ministry of Agriculture and Zhejiang Province for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029, China; College of Life Sciences, Zhejiang University, 310029, China; James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China

^* To whom correspondence should be addressed. Email: yjhua{at}zju.edu.cn.

	Abstract

Here we present direct evidence for the vital role of RecO in Deinococcus radiodurans' radioresistance. A recO null mutant was constructed using a deletion replacement method. The mutant exhibited a growth defect and extreme sensitivity to irradiation with gamma ray and UV light. These results suggest that DNA repair in this organism occurs mainly via the RecF pathway.