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J. Bacteriol. doi:10.1128/JB.01994-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

THE GTPase, CPGA IS IMPLICATED IN THE DEPOSITION OF THE PEPTIDOGLYCAN SACCULUS IN B. SUBTILIS

Université Paris-Sud 11, Institut de Génétique et Microbiologie, CNRS UMR 8621, Bâtiment 409, 91405 Orsay cedex, France; Université Paris-Sud 11, Institut de Biochimie et Biophysique Moléculaire et Cellulaire, CNRS UMR 8619, Bâtiment 430, 91405 ORSAY cedex, France; Institut National de la Santé et de la Recherche Médicale, U-570, CHU Necker, Enfants Malades, 156 rue de Vaugirard, 75730 Paris cedex 15, France; Institut National de la Recherche Agronomique, UR 895 : Génétique microbienne, Dynamique du génome – Génomique, Domaine de Vilvert - 78352 JOUY-EN-JOSAS cedex, France

^* To whom correspondence should be addressed. Email: simone.seror{at}igmors.u-psud.fr.

	Abstract

Depletion of the B. subtilis GTPase CpgA produces abnormal cell shapes, non-uniform deposition of cell wall and 5-6 fold accumulation of peptidoglycan precursors. Nevertheless, the inherent structure of the cell wall appeared mostly unchanged. The results are consistent with CpgA being involved in coordinating normal peptidoglycan deposition.