Cover photograph (Copyright © 1999, American Society for Microbiology. All Rights Reserved.): Appearance
of mismatch-repair-deficient (MMR-) mutator subpopulations as colony sectors. A mutT derivative
of a Bgl- strain was plated on minimal glucose
plates with 5-bromo-4-chloro-3-indolyl-
-D-glucoside.
MMR- sectors (e.g., mutH or mutS) are revealed by frequent blue Bgl+
papillae (demonstrating repeat tract instability). Here, an MMR- mutant has risen at
approximately the fifth cell division, resulting in a thin sector of the colony displaying repeat tract
(or microsatellite) instability. (See related article on page 1576.)
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| Appl. Environ. Microbiol. | Infect. Immun. | Eukaryot. Cell |
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| Mol. Cell. Biol. | J. Virol. | Microbiol. Mol. Biol. Rev. |
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