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Cover photograph (Copyright © 2004, American Society for Microbiology. All Rights Reserved.): The lethality of the Escherichia coli toxin MazF can be prevented by the E. coli antitoxin MazE. However, there is a point of no return after which the downstream effect of MazF cannot be prevented by MazE and cell death is unavoidable. (“A Point of No Return,” painting by Menashe Kadishman.) (See related article on page 8295.)
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