Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Transmission electron micrograph of a negatively stained Pseudomonas aeruginosa cystic fibrosis isolate overexpressing the flagellum regulator FleQ. Increased expression of FleQ bypasses the regulatory circuit controlling normal flagellum number and converts characteristically monoflagellate P. aeruginosa into a hyperflagellated cell that expresses multiple flagella at both poles. (See related article on page 7955.)