Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Cell distribution pattern during biofilm formation. Escherichia coli (MG1655) cells were allowed to attach to a microscope coverslip, and a digital image of the cells was subjected to fast Fourier transform (FFT) analysis. The doughnut-shaped two-dimensional FFT spectrum is indicative of a nonrandom distribution of cells on the glass surface, which is shown to be genetically determined. (See related article on page 8237.)