Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): The gram-negative pathogen Burkholderia pseudomallei is the causative agent of the human disease melioidosis. Shown is a composite image depicting (left to right) a B. pseudomallei DNA microarray, a heat map demonstrating genome-wide regulation of genes from early phase to stationary phase, and a series of natural B. pseudomallei isolates. (Isolate images courtesy of Catherine Ong and Siew Hoon Sim.) (See related article on page 8178.)