Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Pseudocolored scanning electron micrograph (magnification, ×7,800) showing a Vero cell infected with Coxiella burnetii, an obligate intracellular pathogen and the agent of human Q fever. The lumen of the lysosome-like parasitophorous vacuole was exposed using a dry-cleave method to reveal numerous pleomorphic bacteria. C. burnetii genes involved in remodeling this vacuole to promote robust growth are likely conserved among disparate C. burnetii isolates. (Image provided by Elizabeth Fischer of the Rocky Mountain Laboratories Microscopy Unit.) (See related article on page 2309.)