Cover photograph (Copyright © 2008, American Society for Microbiology. All Rights Reserved.): Escherichia coli cells depleted for the shape proteins MreBCD form spheroids with intracytoplasmic membrane systems. Shown are differential interference contrast (left) and fluorescence (right) images of MreBCD-depleted cells of strain FB30/pFB174 stained with the vital membrane dye FM 4-64 (upper panel) or expressing green fluorescent protein targeted for secretion to the periplasm (lower panel). (See related article on page 1792.)