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GENETICS AND MOLECULAR BIOLOGY

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

Ernestina Fernández, Ulrike Weißbach, César Sánchez Reillo, Alfredo F. Braña, Carmen Méndez, Jürgen Rohr, José A. Salas
Ernestina Fernández
Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain;
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Ulrike Weißbach
Institut für Organische Chemie der Universität Göttingen, D-37077 Göttingen, Germany; and
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César Sánchez Reillo
Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain;
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Alfredo F. Braña
Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain;
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Carmen Méndez
Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain;
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Jürgen Rohr
Institut für Organische Chemie der Universität Göttingen, D-37077 Göttingen, Germany; and
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425-2303
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José A. Salas
Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain;
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DOI: 10.1128/JB.180.18.4929-4937.1998
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Article Information

DOI 
https://doi.org/10.1128/JB.180.18.4929-4937.1998
PubMed 
9733697

Published By 
American Society for Microbiology Journals
History 
  • Received May 22, 1998
  • Accepted July 21, 1998
  • Published online September 15, 1998.

Copyright & Usage 
Copyright © 1998 American Society for Microbiology

Author Information

  1. Ernestina Fernández1,
  2. Ulrike Weißbach2,
  3. César Sánchez Reillo1,
  4. Alfredo F. Braña1,
  5. Carmen Méndez1,
  6. Jürgen Rohr2,3* and
  7. José A. Salas1*
  1. Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain1;
  2. Institut für Organische Chemie der Universität Göttingen, D-37077 Göttingen, Germany2; and
  3. Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina 29425-23033
  • ↵* Corresponding author. Mailing address for José A. Salas: Departamento de Biologı́a Funcional e Instituto Universitario de Biotecnologia de Asturias (I.U.B.A.-C.S.I.C.), Universidad de Oviedo, 33006 Oviedo, Spain. Phone and fax: 34-85-103652. E-mail: jasf{at}sauron.quimica.uniovi.es. Mailing address for Jürgen Rohr: Department of Pharmaceutical Sciences, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425-2303. Phone: (843) 953-6659. Fax: (843) 953-6615. E-mail: rohrj{at}musc.edu.

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Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin
Ernestina Fernández, Ulrike Weißbach, César Sánchez Reillo, Alfredo F. Braña, Carmen Méndez, Jürgen Rohr, José A. Salas
Journal of Bacteriology Sep 1998, 180 (18) 4929-4937; DOI: 10.1128/JB.180.18.4929-4937.1998

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Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin
Ernestina Fernández, Ulrike Weißbach, César Sánchez Reillo, Alfredo F. Braña, Carmen Méndez, Jürgen Rohr, José A. Salas
Journal of Bacteriology Sep 1998, 180 (18) 4929-4937; DOI: 10.1128/JB.180.18.4929-4937.1998
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KEYWORDS

Antibiotics, Antineoplastic
Disaccharides
Genes, Bacterial
glycosyltransferases
Plicamycin
Streptomyces

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