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PHYSIOLOGY AND METABOLISM

Positive Correlation between Virulence ofPseudomonas aeruginosa Mutants in Mice and Insects

Georg Jander, Laurence G. Rahme, Frederick M. Ausubel
Georg Jander
Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, 1 and
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Laurence G. Rahme
Department of Surgery, Harvard Medical School, and Shriner's Burns Institute, Massachusetts General Hospital, 2 Boston, Massachusetts 02114
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Frederick M. Ausubel
Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, 1 and
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DOI: 10.1128/JB.182.13.3843-3845.2000
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ABSTRACT

Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.

  • Copyright © 2000 American Society for Microbiology
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Positive Correlation between Virulence ofPseudomonas aeruginosa Mutants in Mice and Insects
Georg Jander, Laurence G. Rahme, Frederick M. Ausubel
Journal of Bacteriology Jul 2000, 182 (13) 3843-3845; DOI: 10.1128/JB.182.13.3843-3845.2000

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Positive Correlation between Virulence ofPseudomonas aeruginosa Mutants in Mice and Insects
Georg Jander, Laurence G. Rahme, Frederick M. Ausubel
Journal of Bacteriology Jul 2000, 182 (13) 3843-3845; DOI: 10.1128/JB.182.13.3843-3845.2000
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