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MOLECULAR BIOLOGY OF PATHOGENS

Simultaneous Coexpression of Borrelia burgdorferi Erp Proteins Occurs through a Specific, erp Locus-Directed Regulatory Mechanism

Nazira El-Hage, Brian Stevenson
Nazira El-Hage
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298
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Brian Stevenson
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298
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  • For correspondence: bstev0@uky.edu
DOI: 10.1128/JB.184.16.4536-4543.2002
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ABSTRACT

An individual Borrelia burgdorferi bacterium can encode as many as 13 different Erp (OspE/F-related) proteins from mono-and bicistronic loci that are carried on up to 10 separate plasmids. We demonstrate through multilabel immunofluorescence analyses that individual bacteria simultaneously coexpress their entire Erp protein repertoire. While it has been proposed that B. burgdorferi controls expression of Erp and other plasmid-encoded proteins through changes in DNA topology, we observed regulated Erp expression in the absence of detectable differences in DNA supercoiling. Likewise, inhibition of DNA gyrase had no detectable effect on Erp expression. Furthermore, expression of loci physically adjacent to erp loci was observed to be independently regulated. It is concluded that Erp expression is regulated by a mechanism(s) directed at erp loci and not by a global, plasmid-wide mechanism.

  • Copyright © 2002 American Society for Microbiology
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Simultaneous Coexpression of Borrelia burgdorferi Erp Proteins Occurs through a Specific, erp Locus-Directed Regulatory Mechanism
Nazira El-Hage, Brian Stevenson
Journal of Bacteriology Aug 2002, 184 (16) 4536-4543; DOI: 10.1128/JB.184.16.4536-4543.2002

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Simultaneous Coexpression of Borrelia burgdorferi Erp Proteins Occurs through a Specific, erp Locus-Directed Regulatory Mechanism
Nazira El-Hage, Brian Stevenson
Journal of Bacteriology Aug 2002, 184 (16) 4536-4543; DOI: 10.1128/JB.184.16.4536-4543.2002
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KEYWORDS

Antigens, Bacterial
Borrelia burgdorferi
Gene Expression Regulation, Bacterial
lipoproteins
Oncogene Proteins
transcription factors

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