DOI: 10.1128/JB.187.1.400-403.2005
ABSTRACT
Nicotinic acid is required by most isolates of Salmonella enterica (serovar Dublin), a pathogen of cattle. A single nadA missense mutation causes the nutritional requirement of all serovar Dublin isolates tested. Models for persistence of this allele are tested and discussed.
- Copyright © 2005 American Society for Microbiology
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- Article
- ABSTRACT
- (i) Relaxed selection for prototrophy.
- (ii) Conditional auxotrophy.
- (iii) Selection for auxotrophy.
- (iv) Mutation pressure.
- Auxotrophy of serovar Dublin isolates.
- Reversion tests.
- Initial evidence for a nadA mutation.
- The serovar Dublin nadA allele is necessary and sufficient for auxotrophy.
- Comparing nadA sequences of enteric bacteria.
- A search for conditions that suppress the auxotrophy of serovar Dublin.
- Pyridine limitation does not provide antibiotic resistance in serovar Dublin.
- Frequency of Nad auxotrophs in natural isolates of S. enterica and E. coli.
- Natural auxotrophy is not associated with mutators or hot spots.
- Summary.
- ACKNOWLEDGMENTS
- FOOTNOTES
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