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PHYSIOLOGY AND METABOLISM

Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of Pseudomonas aeruginosa Physiology

Kelli L. Palmer, Lauren M. Mashburn, Pradeep K. Singh, Marvin Whiteley
Kelli L. Palmer
1Department of Periodontics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
2Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
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Lauren M. Mashburn
1Department of Periodontics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
2Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
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Pradeep K. Singh
3Division of Pulmonary and Critical Care Medicine, The University of Iowa College of Medicine, Iowa City, Iowa 52240
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Marvin Whiteley
1Department of Periodontics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
2Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104
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  • For correspondence: marvin-whiteley@ouhsc.edu
DOI: 10.1128/JB.187.15.5267-5277.2005
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ABSTRACT

The opportunistic human pathogen Pseudomonas aeruginosa causes persistent airway infections in patients with cystic fibrosis (CF). To establish these chronic infections, P. aeruginosa must grow and proliferate within the highly viscous sputum in the lungs of CF patients. In this study, we used Affymetrix GeneChip microarrays to investigate the physiology of P. aeruginosa grown using CF sputum as the sole source of carbon and energy. Our results indicate that CF sputum readily supports high-density P. aeruginosa growth. Furthermore, multiple signals, which reduce swimming motility and prematurely activate the Pseudomonas quinolone signal cell-to-cell signaling cascade in P. aeruginosa, are present in CF sputum. P. aeruginosa factors critical for lysis of the common CF lung inhabitant Staphylococcus aureus were also induced in CF sputum and increased the competitiveness of P. aeruginosa during polymicrobial growth in CF sputum.

  • Copyright © 2005 American Society for Microbiology
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Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of Pseudomonas aeruginosa Physiology
Kelli L. Palmer, Lauren M. Mashburn, Pradeep K. Singh, Marvin Whiteley
Journal of Bacteriology Jul 2005, 187 (15) 5267-5277; DOI: 10.1128/JB.187.15.5267-5277.2005

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Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of Pseudomonas aeruginosa Physiology
Kelli L. Palmer, Lauren M. Mashburn, Pradeep K. Singh, Marvin Whiteley
Journal of Bacteriology Jul 2005, 187 (15) 5267-5277; DOI: 10.1128/JB.187.15.5267-5277.2005
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KEYWORDS

Pseudomonas aeruginosa

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