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ENZYMES AND PROTEINS

Role of the Campylobacter jejuni Cj1461 DNA Methyltransferase in Regulating Virulence Characteristics

Joo-Sung Kim, Jiaqi Li, If H. A. Barnes, David A. Baltzegar, Mohanasundari Pajaniappan, Thomas W. Cullen, M. Stephen Trent, Christopher M. Burns, Stuart A. Thompson
Joo-Sung Kim
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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Jiaqi Li
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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If H. A. Barnes
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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David A. Baltzegar
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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Mohanasundari Pajaniappan
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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Thomas W. Cullen
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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M. Stephen Trent
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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Christopher M. Burns
2College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431
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Stuart A. Thompson
1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
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  • For correspondence: stthomps@mcg.edu
DOI: 10.1128/JB.00765-08
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Article Information

DOI 
https://doi.org/10.1128/JB.00765-08
PubMed 
18689478

Published By 
American Society for Microbiology Journals
History 
  • Received May 29, 2008
  • Accepted July 21, 2008
  • Published online September 15, 2008.

Copyright & Usage 
Copyright © 2008 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (August 08, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Joo-Sung Kim1,
  2. Jiaqi Li1,
  3. If H. A. Barnes1,
  4. David A. Baltzegar1,
  5. Mohanasundari Pajaniappan1,
  6. Thomas W. Cullen1,
  7. M. Stephen Trent1,
  8. Christopher M. Burns2 and
  9. Stuart A. Thompson1*
  1. 1Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912
  2. 2College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 33431
  • ↵* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912. Phone: (706) 721-7277. Fax: (706) 721-6608. E-mail: stthomps{at}mcg.edu
  • † Supplemental material for this article may be found at http://jb.asm.org/ .

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Role of the Campylobacter jejuni Cj1461 DNA Methyltransferase in Regulating Virulence Characteristics
Joo-Sung Kim, Jiaqi Li, If H. A. Barnes, David A. Baltzegar, Mohanasundari Pajaniappan, Thomas W. Cullen, M. Stephen Trent, Christopher M. Burns, Stuart A. Thompson
Journal of Bacteriology Sep 2008, 190 (19) 6524-6529; DOI: 10.1128/JB.00765-08

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Role of the Campylobacter jejuni Cj1461 DNA Methyltransferase in Regulating Virulence Characteristics
Joo-Sung Kim, Jiaqi Li, If H. A. Barnes, David A. Baltzegar, Mohanasundari Pajaniappan, Thomas W. Cullen, M. Stephen Trent, Christopher M. Burns, Stuart A. Thompson
Journal of Bacteriology Sep 2008, 190 (19) 6524-6529; DOI: 10.1128/JB.00765-08
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  • Top
  • Article
    • ABSTRACT
    • Cj1461 is a DNA MTase but is not a Dam ortholog.
    • Generation of cj1461 mutant and complemented strains.
    • Mutation of cj1461 causes a motility defect.
    • Mutation of cj1461 causes a defect in flagellar appearance.
    • cj1461 mutation causes hyperadherence to but decreased invasion of INT-407 cells.
    • Conclusion.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

Bacterial Proteins
Campylobacter jejuni
DNA Modification Methylases

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